For more information

Dept. of Dermatology
Mail Code: L468R
Oregon Health & Science University
3181 SW Sam Jackson Park Rd.
Portland, OR 97239

Office: (503) 418-4273
Fax: (503) 418-4266

info(at)
montagnasymposium.org

Molly Kulesz-Martin, Ph.D.
Symposium Director

David Norris, M.D.
Jackie Bickenbach, Ph.D.
Symposium Director Emeriti

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2018 Preliminary Program - Schedule subject to change
Wednesday, October 17, 2018

1:00 pm to 6:00 pm

Melanoma, Vitiligo & XP Patient Symposium

1:00 pm to 2:00 pm

LUNCH

2:00 pm to 2:45 pm

Keynote:
It's all about the melanocyte.
Sancy A. Leachman, MD, PhD, Oregon Health & Science University

2:45 pm to 3:45 pm

Exhibits

3:45 pm to 5:45 pm

Breakout Sessions - Melanoma, Vitiligo & XP

6:00 pm to 8:00 pm

OPENING SESSION

Reception and welcome:
Sancy Leachman, MD, PhD, Oregon Health & Science University

Keynote:
Pigeons as a model system for human disease.
Michael Shapiro, PhD, University of Utah

Thursday, October 18, 2018
7:00 am to 7:55 am

BREAKFAST

8:00 am to 8:15 am

Acknowledgments

8:15 am to 11:30 am

Session 1: Animal Models

Chairs:
Greg Barsh, MD, PhD, HudsonAlpha Institute for Biotechnology
Sheri L. Holmen, PhD, University of Utah

8:25 am to 8:55 am

Session Keynote:
Unraveling the thread of nature's tapestry: The genetics of diversity and convergence in animal pigmentation.
Greg Barsh, MD, PhD, HudsonAlpha Institute for Biotechnology

8:55 am to 9:55 am

Invited Speakers:
Models of melanoma metastasis.
Sheri L. Holmen, PhD, University of Utah

Initiation and progression of BRAF/NRAS wildtype melanoma in a UV-induced mouse model of cutaneous melanoma.
Helen Michael, DVM, National Institutes of Health

9:55 am to 10:15 am

BREAK

10:15 am to 11:00 am

Short Talks

11:00 am to 11:30 am

Invited Speaker:
Models of melanoma immunosuppression.
Barbara Bedogni, PhD, University of Miami

11:30 am to 12:45 pm

LUNCH
PASPCR General Meeting

12:45 pm to 4:45 pm

Session 2: Human Model Systems

Chairs:
James E. Cleaver, PhD,
University of California San Francisco
Kenneth A. Kraemer, MD, National Cancer Institute,Center for Cancer Research

12:55 pm to 1:25 pm

Session Keynote:
Genetics and melanoma.
Hensin Tsao, MD, PhD, Harvard University

1:25 pm to 2:25 pm

Invited Speakers:
Xeroderma pigmentosum as a model system.
Kenneth A. Kraemer, MD, National Cancer Institute,Center for Cancer Research

A 40-year followup of familial melanoma.
Margaret A. Tucker, MD, National Cancer Institute

2:25 pm to 2:35 pm

BREAK

2:35 pm to 3:05 pm

Invited Speaker:
High risk skin cancer populations.
Sarah Arron, MD, PhD, University of California, San Francisco

3:05 pm to 3:35 pm

Short Talks

3:35 pm to 3:45 pm

BREAK

3:45 pm to 4:15 pm

Short Talks

4:15 pm to 4:45 pm

Point/Counterpoint Discussion: Sun and sunscreens: Good or bad?

4:45 pm to 7:00 pm

Poster Session I & Reception

Chair:
Cynthia Cooper, PhD, Washington State University

Young Investigator "Microtalks"

Friday, October 19, 2018
7:00 am to 7:55 am

BREAKFAST

8:00 am to 8:15 am

Presentation of Travel Awards

8:15 am to 11:45 pm

Session 3: Stem Cells and Development

Chairs:
Mayumi Fujita, MD, PhD,
University of Colorado Denver
William J. Pavan, PhD, National Institutes of Health & National Human Genome Research Institute

8:25 am to 8:55 am

Session Keynote:
Zebrafish pigmentation stem cells.
David Parichy, PhD,
University of Virginia

8:55 am to 9:55 am

Invited Speakers:
Melanocyte stem cells and melanoma.
Emi K. Nishimura, MD, PhD, Tokyo Medical and Dental University Japan

Melanocyte development (and melanoma) in zebrafish.
E. Elizabeth Patton, PhD, University of Edinburgh

9:55 am to 10:15 am

BREAK

10:15 am to 10:45 am

Short Talks

10:45 am to 11:45 am

Invited Speakers:
Melanocyte stem cells and skin regeneration.
Mayumi Ito, PhD, New York University

Exploiting mouse models of hair graying to identify and investigate novel aspects of stem cell biology.
Melissa L. Harris, PhD, University of Alabama Birmingham

11:45 am to 12:45 pm

LUNCH
PASPCR Council Meeting

12:45 pm to 4:45 pm

Session 4: Microenvironment and Immunology

Chairs:
I. Caroline Le Poole, PhD,
Northwestern University
Amanda Lund, PhD, Oregon Health & Science University

12:55 pm to 1:25 pm

Session Keynote:
Vitiligo development for melanoma survival.
Rosalie Luiten, PhD,
University of Amsterdam

1:25 pm to 2:25 pm

Invited Speakers:
Melanoma-induced inflammation and immunosuppression. Mayumi Fujita, MD, PhD, University of Colorado

Lymphatic vessels as selective barriers to anti-tumor immunity in melanoma.
Amanda Lund, PhD,
Oregon Health & Science University

T cells in vitiligo.
I. Caroline LePoole, PhD, Northwestern University

2:25 pm to 2:35 pm

BREAK

2:35 pm to 3:35 pm

Short Talks

3:35 pm to 3:45 pm

BREAK

3:45 pm to 4:15 pm

Invited Speaker:
A novel biology for PD1 in melanoma and barrier immunity
Niroshana Anandasbapathy, MD, PhD,
Harvard Medical School

4:15 pm to 4:45 pm

Point/Counterpoint Discussion: Vitiligo/immunology topic TBD

4:45 pm to 7:00 pm

Poster Session 2 & Reception

Chair: Arup Indra, PhD, Oregon State University

Young Investigator "Microtalks"

Saturday, October 20, 2018
7:00 am to 7:55 am

BREAKFAST

8:00 am to 8:15 am

Announcements

8:15 am to 12:00 pm

Session 5: Genetics, Early Detection and Prevention

Chairs:
Boris Bastian, MD, PhD, University of California, San Francisco
Sancy Leachman, MD, PhD, Oregon Health & Science University

8:25 am to 8:55 am

Session Keynote:
Genomics and pigmentation.
William J. Pavan, PhD, National Human Genome Research Institute

8:55 am to 9:55 am

Invited Speakers:
Chemopreventives on the horizon.
Pamela Cassidy, PhD, Oregon Health & Science University

New technologies for melanoma diagnosis and treatment.
Iweh Yeh, MD, PhD, University of California, San Francisco

9:55 am to 10:15 am

BREAK

10:15 am to 10:45 am

Invited Speakers:
The genetic architecture of vitiligo
Richard Spritz, PhD, University of Colorado

10:45 am to 11 am
Short Talk
11 am to 11:30 am

Special Talk
The squid's version of a vertebrate melanocyte: a dynamic chromatocyte with pigmentary and structural coloration components.
Roger Hanlon,PhD, Marine Biological Laboratory/Brown University

11:15 am to 11:30 am

Point/Counterpoint Discussion: Dysplastic nevi: Precursor or not?

12:00 pm to 6:15 pm

Lunch on own; organized hike or free time

6:15 pm to 8:15 pm

DINNER SESSION

Keynote:
How the microenvironment influences disease progression and therapeutic opportunities.
Lisa Coussens, PhD,
Oregon Health & Science University

Sunday, October 21, 2018
7:00 am to 7:55 am

BREAKFAST

8:00 am to 8:15 am

Announcements

8:15 am to 11:45 pm

Session 6: Signal Transduction

Chairs:
John A. D'Orazio, MD, PhD, University of Kentucky
Roger S. Lo, MD, PhD, University of California Los Angeles
Vijay Setaluri, PhD, University of Wisconsin - Madison

8:25 am to 8:55 am

Session Keynote (PASPCR):
Signaling pathways and ER stress response in melanoma.
Ze'ev Ronai, PhD, Sanford Burnham Presbys Medical Discovery Institute and Technion - Israel Institute of Technology

8:55 am to 9:55 am

Invited Speakers:
Tyrosine kinase activation in melanoma.
Neal Rosen, MD, PhD
, Memorial Sloan Kettering Cancer Center

Personalized therapy for melanoma subgroups.
Keiran S. Smalley, PhD,
Moffitt Cancer Center

9:55 am to 10:15 am

BREAK

10:15 am to 11:15 am

Short Talks

11:15 am to 11:45 am

Invited Speaker:
Melanoma therapeutics.
Roger S. Lo, MD, PhD, University of California Los Angeles

11:45 am to 12:45 pm

LUNCH

12:45 pm to 4:45 pm

Session 7: Photochemistry and Toxicology of Pigment Cells

Chairs:
Douglas E. Brash, PhD, Yale University
Prashiela Manga, PhD, New York University

12:55 pm to 1:25 pm

Session Keynote (PASPCR):
Role of melanin excited states: Genome-wide distribution of cyclobutane dimers
Douglas E. Brash, PhD, Yale University

1:25 pm to 2:25 pm

Invited Speakers:
Redox properties of melanin and its potential for drug interactions: Revealing redox-features through electrochemical reverse engineering.
Gregory F. Payne, PhD, University of Maryland

Stress-response pathways activated in response to vitiligo-inducing phenols.
Prashiela Manga, PhD, New York University

2:25 pm to 2:35 pm

BREAK

2:35 pm to 3:05 pm

Short Talks

3:05 pm to 3:15 pm

BREAK

3:15 pm to 4:15 pm

Invited Speakers:
Neuromelanin in human brain aging and Parkinson disease.
Luigi Zecca, MD, PhD, Institute of Biomedical Technologies, National Research Council of Italy

Melanin-mediated cancer immunotherapy.
Zhen Gu, PhD, University of California, Los Angeles

4:15pm to 4:45 pm

Point/Counterpoint Discussion: Antioxidants: Good or bad?

6:00 pm to 8:30 pm

Northwest Salmon Barbecue
On the beach (weather permitting)

Monday, October 22, 2018
7:00 am to 8:30 am

Breakfast & departure

Funding for this conference was made possible (in part) by (2 R13AR009431-53) and (1 R13AR07429-01) from the National Institute Of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and all cofunding support provided the National Institute on Aging (NIA) and the National Institute of Environmental Sciences (NIEHS). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.