Program subject to change
2023:
Visualizing the Future of Skin Biology and Dermatology
The 70th anniversary Montagna Symposium on the Biology of Skin, chaired by Dr. Dennis Roop, will take a broad look into the future of skin biology and Dermatology and include sessions on Skin Cancers, Tissue Repair and Fibrosis, Skin Inflammation and Keratinocyte – Immune Cell Cross-talk, and Emerging Therapeutic Approaches. Joe Gray, Ph.D. (OHSU) will provide the keynote speech.
Program Chair and Symposium Co-director
Dennis Roop, Ph.D.
Symposium Co-director
Sancy Leachman, M.D., Ph.D.
Symposium Co-organizers
Stuart Yuspa, M.D.
Thomas Krieg, M.D., Ph.D.
Sabine Werner, Ph.D.
Session 1: Skin Cancer; Chair: Stuart Yuspa, M.D. (NIH)
Session 2: Tissue Repair and Fibrosis; Chair: Thomas Krieg, M.D., Ph.D. (Cologne)
Session 3: Keratinocyte – Immune Cell Cross-talk in Skin Inflammation; Chair: Sabine Werner, Ph.D. (ETH Zurich)
Session 4: Emerging Diagnostic and Therapeutic Approaches; Chairs: Dennis Roop, Ph.D. (Colorado), Sancy Leachman, M.D., Ph.D. (OHSU)
*Note: The Montagna Sympsium is approved for Continuing Medical Education (CME). See bottom of this page for details*
Thursday, Oct 19 | |
| 2:00 p.m. – 4:00 p.m. | Shuttle Bus from PDX Leaves (reservation required) |
| 4:00 p.m. – 7:00 p.m. | Arrival and Check-in |
| 6:00 p.m. – 7:00 p.m. | Welcome Reception and introductory comments Sancy Leachman, M.D., Ph.D. (OHSU) and Dennis Roop, Ph.D. (Colorado)Dinner Buffet |
| 7:15 p.m. – 8:15 p.m. | Keynote: Joe Gray, Ph.D. (OHSU) “Rethinking precision cancer treatment for advanced cancers – a systems biomedicine approach” |
Friday, Oct 20 | |
| 7:00 a.m. – 8:00 a.m. | Breakfast |
| 8:00 a.m. – 8:15 a.m. | Introductory Remarks Dennis Roop, Ph.D. (Colorado) and Sancy Leachman, M.D. Ph.D. (OHSU) |
| 8:15 a.m. – 8:25 a.m. | Session 1: Advances in skin cancer research and therapy Session Moderator: Stuart Yuspa, M.D. (NIH) |
| 8:25 a.m. – 8:55 a.m. | Allan Balmain, Ph.D. (UCSF) “Squamous cancer, pre-cancer, insights on tumor promotion.” (CME) |
| 8:55 a.m. – 9:05 a.m. | Discussion |
| 9:05 a.m. – 9:35 a.m. | Andrzej Dlugosz, M.D. (Michigan) “Cell fate reprogramming to drive Merkel cell carcinoma development in mice” (CME) |
| 9:35 a.m. – 9:45 a.m. | Discussion |
| 9:45 a.m. – 10:15 a.m. | Sergey Nikolaev, M.D. (Gustave Roussey, Paris) “Basal Cell Carcinoma (From functional genomics to the mechanisms of treatment resistance)” (CME) |
| 10:15 a.m. – 10:25 a.m. | Discussion |
| 10:25 a.m. – 10:35 a.m. | Break |
| 10:35 a.m. – 11:05 a.m. | Brigitte Widemann, M.D. (NIH) “Current understanding of pathogenesis and treatment of Neurofibromatosis 1 related peripheral nerve sheath tumors” (CME) |
| 11:05 a.m. – 11:15 a.m. | Discussion |
| 11:15 a.m. – 11:45 a.m. | Stephanie Goff, M.D. (NIH) “Cell-based immunotherapy for melanoma” (CME) |
| 11:45 a.m. – 11:55 a.m. | Discussion |
| 11:55 a.m. – 12:10 p.m. | Paolo Vignali, Ph.D. (University of Pittsburgh) “Hypoxia within melanoma tumors promotes an unappreciated suppressor function in exhausted T cells and limits antitumor immunity” |
| 12:10 p.m. – 12:25 p.m. | Stephanie Holtorf (University of Minnesota) “Identifying a novel population of epithelial cells in the blood and bone marrow of normal mice and humans” |
| 12:25 – 1:15 p.m. | Lunch |
| 1:15 p.m. – 1:20 p.m. | Session 2: Tissue Repair and Fibrosis Session Moderator: Thomas Krieg, M.D. (Cologne) |
| 1:20 p.m. – 1:50 p.m. | Thomas Krieg, M.D. (Cologne) “Regulation of Fibroblast Activities – Implications for Tissue Repair and Fibrosis” (CME) |
| 1:50 p.m. – 2:00 p.m. | Discussion |
| 2:00 p.m. – 2:30 p.m. | Maksim Plikus, Ph.D. (UC Irvine) “Use of palmo-plantar fibroblasts to reprogram stump skin in amputees to enhance prosthetic use” |
| 2:30 p.m. – 2:40 p.m. | Discussion |
| 2:40 p.m. – 3:10 p.m. | Michael Longaker, M.D. (Stanford) “Fibroblasts subsets, and the identification of specific signatures and their involvement in scar formation” |
| 3:10 p.m. – 3:20 p.m. | Discussion |
| 3:20 p.m. – 3:30 p.m. | Break |
| 3:30 p.m. – 4:00 p.m. | Sabine Eming, M.D. (Cologne) “Macrophage subsets and the role of reparative macrophages in remodeling the extracellular matrix” (CME) |
| 4:00 p.m. – 4:10 p.m. | Discussion |
| 4:10 p.m. – 4:40 p.m. | Alexander Marneros, M.D., Ph.D. (Harvard) “Aplasia cutis pathogenesis reveals mechanisms regulating skin formation and tissue fibrosis” (CME) |
| 4:40 p.m. – 4.50 p.m. | Discussion |
| 4:50 p.m. – 5:20 p.m. | Xiao-Jing Wang, M.D., Ph.D. (UC Davis) “Therapeutic effects of Smad7-based protein on dermatitis through upregulation of IL22RA2” |
| 5:20 p.m. – 5:30 p.m. | Discussion |
| 5:30 p.m. – 5:45 p.m. | Suneeti Madhavan (Case Western) “WNT signaling activation causes early decline of de novo lipogenesis leading to lipid depleted dermal adipocytes” |
| 5:45 p.m. – 6:00 p.m. | Ian Odell, M.D., Ph.D. (Yale) “IL-6 Trans-Signaling in a Humanized Mouse Model of Scleroderma” |
| 6:00 p.m. – 7:00 p.m. | Dinner Awards Presentation · Society of Investigative Dermatology Eugene M. Farber Travel Awards for Young Investigators · Japanese Society for Investigative Dermatology Travel Award · Korean Society for Investigative Dermatology Travel Award · Taiwanese Society for Investigative Dermatology (TSID) Award · European Society for Dermatological Research: ESDR Travel Award · Director’s Award for Diversity |
| 7:00 p.m. – 9:00 p.m. | Poster Reception (Dessert and wine tasting) |
Saturday, Oct 21 | |
| 7:00 a.m. – 8:00 a.m. | Breakfast |
| 8:00 a.m. – 8:05 a.m. | Announcements |
| 8:05 a.m. – 8:10 a.m. | Session 3: Keratinocyte – Immune Cell Cross-talk in Skin Inflammation Session Moderator: Sabine Werner, M.D. (ETH, Zurich) |
| 8:10 a.m. – 8:40 a.m. | Sara Brown, M.D. (Edinburgh) “Keratinocytes are immunologically-active cells in their own right: evidence from genetic studies and primary cell culture” (CME) |
| 8:40 a.m. – 8:50 a.m. | Discussion |
| 8:50 a.m. – 9:20 a.m. | Michel Gilliet, M.D. (Lausanne) “Reciprocal immune-keratinocyte interactions in the pathogenesis of psoriasis” (CME) |
| 9:20 a.m. – 9:30 a.m. | Discussion |
| 9:30 a.m. – 10:00 a.m. | Shruti Naik, Ph.D. (NYU) “Targeting immune-epithelial circuits in inflammatory skin disease” (CME) |
| 10:00 a.m. – 10:10 a.m. | Discussion |
| 10:10 a.m. – 10:20 a.m. | Break |
| 10:20 a.m. – 10:50 a.m. | Sabine Werner, M.D. (ETH, Zurich) “Keratinocytes: key regulators of stromal and immune cell functions in tissue repair and cancer” (CME) |
| 10:50 a.m. – 11:00 a.m. | Discussion |
| 11:00 a.m. – 11:15 a.m. | Ricardo Cibotti, Ph.D. (NIH) “NIH/NIAMS Funding Opportunities” |
| 11:15 a.m. – 11:30 a.m. | Benjamin Klein, M.D. (Michigan) “Mitochondrial Z-DNA and ZBP1 Drive Autoimmune Photosensitivity” |
| 11:30 a.m. – 11:45 a.m. | Jared Simmons (UC San Diego) “Dermal fibroblasts have a critical role in skin immunity through responses to keratinocyte interleukin-1” |
| 11:45 a.m. | Lunch (on your own) |
| 11:45 a.m. – 4:00 p.m. | FREE TIME / GOLF / CASCADE HIKE – Group Hike: Meet in the lobby at 12:30pm – Golf and Activities: salishan.com/adventure |
| 4:30 p.m. – 6:00 p.m. | Round Table Discussions All attendees are welcome to participate. Please sign up for your top two choices, we will organize to keep the groups appropriately small, and there will be a chance to move to a new group halfway through.
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| 6:00 p.m. – 7:30 p.m. | Dinner History and Future of Montagna |
| 7:30 p.m. – 10:00 p.m. | Molly Kulesz-Martin, Ph.D., Director Emeritus, Retirement Celebration |
Sunday, Oct 22 | |
| 7:00 a.m. – 8:00 a.m. | Breakfast |
| 8:00 a.m. – 8:05 a.m. | Announcements |
| 8:05 a.m. – 8:10 a.m. | Session 4: Emerging Diagnostic and Therapeutic Approaches Session Moderator: Dennis Roop, Ph.D. (Colorado) |
| 8:10 a.m. – 8:40 a.m. | Tony Oro, M.D., Ph.D. (Stanford) “A Spatiotemporal and Machine-Learning Platform to Accelerate hPSC-derived Tissue Replacement” (CME) |
| 8:40 a.m. – 8:50 a.m. | Discussion |
| 8:50 a.m. – 9:20 a.m. | Ganna Bilousova, Ph.D. (Colorado) “An Autologous iPSC-based Therapy for Recessive Dystrophic Epidermolysis Bullosa Delivered via Cell Suspension” (CME) |
| 9:20 a.m. – 9:30 a.m. | Discussion |
| 9:30 a.m. – 10:00 a.m. | Peter Marinkovich, M.D. (Stanford) “Bench to bedside development of the first FDA approved gene therapy for dystrophic epidermolysis bullosa” (CME) |
| 10:00 a.m. – 10:10 a.m. | Discussion |
| 10:10 a.m. – 10:20 a.m. | Break |
| 10:20 a.m. – 10:35 a.m. | Martin Alphonse, Ph.D. (Johns Hopkins) “Inflammasome-mediated host defense against Staphylococcus aureus skin infections is mediated by neutrophil-intrinsic NLRP12 and caspase-8 signaling” |
| 10:35 a.m. – 10:50 a.m. | Jenna Bowman (OHSU) “Patient-Specific Targeting of the T-Cell Receptor Variable Region as a Therapeutic Strategy in Clonal T-Cell Diseases” |
| 10:50 a.m. – 11:20 a.m.
| Luis Garza, M.D., Ph.D. (Johns Hopkins) “In human use of fibroblasts to modify skin identity” (CME) |
| 11:20 a.m. – 11:30 a.m. | Discussion |
| 11:30 a.m. – 12:00 p.m. | Christoph Ellebrecht, M.D. (UPenn) “Leveraging asymmetric cell division in CAR/CAAR T cells for optimized precision immunotherapy of pemphigus and other autoimmune conditions” (CME) |
| 12:00 p.m. – 12:10 p.m. | Discussion |
| 12:10 a.m. – 1:30 p.m. | Lunch David Hyams, M.D., F.A.C.S. |
| 1:30 p.m. – 2:00 p.m. | David Huang, M.D., Ph.D. (OHSU) “Optical coherence tomography and angiography: technology development and potential applications in the skin” (CME) |
| 2:00 p.m. – 2:10 p.m. | Discussion |
| 2:10 p.m. – 2:25 p.m. | Favour Akinjiyan (Washington University in St. Louis) “Exploring DDR2’s role in CAF extracellular matrix production and tumor progression” |
| 2:25 p.m. – 2:40 p.m. | Meagan Branch (Mount Sinai) “The epigenetic control of re-epithelialization during adult skin wound healing” |
| 2:40 p.m. – 3:40 p.m. | Panel Discussion Visualizing the Future of Dermatology and Skin Biology: Industry Perspectives |
| 3:40 p.m.- 4:30 p.m. | Open Time – Option to take the shuttle (5 minutes) to the beach Program Committee Business Meeting |
| 4:30 p.m. – 7:30 p.m. | Salmon Bake Dinner at the Beach House |
Monday Oct 23 | |
| 6 a.m. – 8:00 a.m. | Breakfast and depart |
| 8:30 a.m. | Bus departs for PDX Airport |
| ~11:30 a.m. | Bus arrives at PDX Airport |
Sponsor Acknowledgement
The Montagna Symposium on the Biology of Skin is made possible due to NIH Grant Number 2 R13 AR009431-56 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases and our generous sponsors:
Champion Level Sponsors
| Castle Bioscience |  |
| LEO Foundation |  |
Sustainer Level Sponsors
| Pfizer Dermatology |  |
Benefactor Level Sponsors
| David M.C. Ju Foundation |  |
| Janssen |  |
Patron Level Sponsors
Associate Level Sponsors
| Knight Cancer Institute |  |
| CTA Pathology |  |
| Biology of Skin Foundation |  |
| Orlucent |  |
| Lumo Imaging |  |
| Sklip Inc. |  |
| EltaMD |  |
Travel Awards made possible thanks to:
- Society for Investigative Dermatology (Eugene Farber Awards)
- Japanese Society for Investigative Dermatology
- Korean Society for Investigative Dermatology
- Taiwanese Society for Investigative Dermatology
- European Society for Dermatological Research
- Montagna Symposium Director’s Award for Diversity